Silicone pipes can be a bit of a mess, but there are a few simple ways to clean them. The first is to use a mild soap and water solution to clean the inside of the pipe. This will remove any built-up dirt and debris that may have been on the outside of the pipe. Another way to clean a silicone pipe is to use a vacuum cleaner with the hose attachment. This will suck all of the dirt and debris out of the silicone pipe.